Latest Overview of the Cyclin-Dependent Kinases 4/6 Inhibitors in Breast Cancer: The Past, the Present and the Future
Identifieur interne : 000693 ( Main/Exploration ); précédent : 000692; suivant : 000694Latest Overview of the Cyclin-Dependent Kinases 4/6 Inhibitors in Breast Cancer: The Past, the Present and the Future
Auteurs : Xiu Chen [République populaire de Chine] ; Di Xu [République populaire de Chine] ; Xingjiang Li [République populaire de Chine] ; Jian Zhang [République populaire de Chine] ; Weilin Xu [République populaire de Chine] ; Junchen Hou [République populaire de Chine] ; Wei Zhang [République populaire de Chine] ; Jinhai Tang [République populaire de Chine]Source :
- Journal of Cancer [ 1837-9664 ] ; 2019.
Abstract
Endocrine resistance in hormone receptor positive breast cancer patients urges us to develop novel approaches such as inhibitors of the cyclin-dependent kinases (CDK) 4/6 to reverse its resistance. Nowadays, three selective CDK4/6 inhibitors (Palbociclib, Ribociclib and Abemaciclib) are approved by Federal Drug Administration and the European Medicines Agency for the treatment of advanced and metastatic HR+/HER2- breast cancer. However, no consistent conclusion has been reached to its application in other types of breast cancer. Therefore, the purpose of our study was to overview the clinical trials about the beneficial effects of Palbociclib, Ribociclib and Abemaciclib in breast cancer with their tolerable adverse effects, and discuss their resistant mechanisms thus looking for useful biomarkers to predict the efficiency of the CDK4/6 inhibitors. The CDK4/6 inhibitors application after the support of preclinic and clinic data will be helpful to provide other alternatively suitable strategies for different types of breast cancer patients.
Url:
DOI: 10.7150/jca.33079
PubMed: 31777590
PubMed Central: 6856891
Affiliations:
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sort="Chen, Xiu" uniqKey="Chen X" first="Xiu" last="Chen">Xiu Chen</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation></author><author><name sortKey="Xu, Di" sort="Xu, Di" uniqKey="Xu D" first="Di" last="Xu">Di Xu</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation></author><author><name sortKey="Li, Xingjiang" sort="Li, Xingjiang" uniqKey="Li X" first="Xingjiang" last="Li">Xingjiang Li</name><affiliation wicri:level="1"><nlm:aff id="A2">Changzhou Wujin People's Hospital, Changzhou, Jiangsu, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Changzhou Wujin People's Hospital, Changzhou, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Jian" sort="Zhang, Jian" uniqKey="Zhang J" first="Jian" last="Zhang">Jian Zhang</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation></author><author><name sortKey="Xu, Weilin" sort="Xu, Weilin" uniqKey="Xu W" first="Weilin" last="Xu">Weilin Xu</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation></author><author><name sortKey="Hou, Junchen" sort="Hou, Junchen" uniqKey="Hou J" first="Junchen" last="Hou">Junchen Hou</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Wei" sort="Zhang, Wei" uniqKey="Zhang W" first="Wei" last="Zhang">Wei Zhang</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation></author><author><name sortKey="Tang, Jinhai" sort="Tang, Jinhai" uniqKey="Tang J" first="Jinhai" last="Tang">Jinhai Tang</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of Cancer</title><idno type="eISSN">1837-9664</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Endocrine resistance in hormone receptor positive breast cancer patients urges us to develop novel approaches such as inhibitors of the cyclin-dependent kinases (CDK) 4/6 to reverse its resistance. Nowadays, three selective CDK4/6 inhibitors (Palbociclib, Ribociclib and Abemaciclib) are approved by Federal Drug Administration and the European Medicines Agency for the treatment of advanced and metastatic HR+/HER2- breast cancer. However, no consistent conclusion has been reached to its application in other types of breast cancer. Therefore, the purpose of our study was to overview the clinical trials about the beneficial effects of Palbociclib, Ribociclib and Abemaciclib in breast cancer with their tolerable adverse effects, and discuss their resistant mechanisms thus looking for useful biomarkers to predict the efficiency of the CDK4/6 inhibitors. The CDK4/6 inhibitors application after the support of preclinic and clinic data will be helpful to provide other alternatively suitable strategies for different types of breast cancer patients.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Steger, G G" uniqKey="Steger G">G G Steger</name></author><author><name sortKey="Gnant, M" uniqKey="Gnant M">M Gnant</name></author><author><name sortKey="Bartsch, R" uniqKey="Bartsch R">R Bartsch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rugo, Hs" uniqKey="Rugo H">HS Rugo</name></author><author><name sortKey="Vidula, N" uniqKey="Vidula N">N Vidula</name></author><author><name sortKey="Ma, C" uniqKey="Ma C">C Ma</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Demichele, A" uniqKey="Demichele A">A DeMichele</name></author><author><name sortKey="Clark, As" uniqKey="Clark A">AS Clark</name></author><author><name 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Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Laroche Clary, A" uniqKey="Laroche Clary A">A Laroche-Clary</name></author><author><name sortKey="Chaire, V" uniqKey="Chaire V">V Chaire</name></author><author><name sortKey="Algeo, M P" uniqKey="Algeo M">M P Algeo</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Chen, Xiu" sort="Chen, Xiu" uniqKey="Chen X" first="Xiu" last="Chen">Xiu Chen</name></noRegion><name sortKey="Hou, Junchen" sort="Hou, Junchen" uniqKey="Hou J" first="Junchen" last="Hou">Junchen Hou</name><name sortKey="Li, Xingjiang" sort="Li, Xingjiang" uniqKey="Li X" first="Xingjiang" last="Li">Xingjiang Li</name><name sortKey="Tang, Jinhai" sort="Tang, Jinhai" uniqKey="Tang J" first="Jinhai" last="Tang">Jinhai Tang</name><name sortKey="Xu, Di" sort="Xu, Di" uniqKey="Xu D" first="Di" last="Xu">Di Xu</name><name sortKey="Xu, Weilin" sort="Xu, Weilin" uniqKey="Xu W" first="Weilin" last="Xu">Weilin Xu</name><name sortKey="Zhang, Jian" sort="Zhang, Jian" uniqKey="Zhang J" first="Jian" last="Zhang">Jian Zhang</name><name sortKey="Zhang, Wei" sort="Zhang, Wei" uniqKey="Zhang W" first="Wei" last="Zhang">Wei Zhang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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